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TU Dressden BIOMOD Find'n'Bind

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It is a constant struggle. ♪[laser blast] The battles have been waging since a long, long time ago. It is a galactic war in our own bodies where our own armies -- our healthy cells -- get killed. We don’t need to quote statistics ♪[hospital noise] to describe the harsh reality of cancer in its various forms [lights flicker] or the reality of chemotherapy and uncertainty of aggressive treatments. Cancer cells are cells that don’t stop dividing and take over. Cancer is not a rare battle for one-in-a-million. Millions of people fight every day, everywhere. Many drugs have been used to take out cancer and one way to introduce them into the body is using liposomes. A liposome is like a tiny bubble made up of the same materials used in the cell membrane called a lipid bilayer. Inside this little bubble, drugs can be stored but they still need to find the cancer cell. Antibodies bind very specific proteins. Like proteins expressed only in cancer cells, and not in healthy cells. Now the drugs are right where they should be. But they are still in the liposome! We must have a new hope. To solve this issue the TU Dresden BIOMOD team designed a novel two-component system... Find’n’Bind! In addition to the liposome, a release mechanism will be introduced. This tiny, 15 nm, gold particle has a special kind of peptide to break the liposome. A different antibody that is also specific to cancer cells is attached. We saw that if the liposome binds alone, drugs are not released. Similarly, the peptides by themselves will not do anything. When, and only when, both the immunoliposome and the gold nanoparticle bind to the cell the peptides will break open the lipid layer releasing drugs that are ready for action. This Find’n’Bind system is extra special because it can be tailored to specific cancers. The antibodies can be changed depending on the cancer type and which antigens are expressed on their surface. The drugs being transported can also, of course, be changed. This modular system is simple, and adaptable making is more feasible for pharmaceutical markets than some other immunoliposome systems that have complicated surface modifications. Most importantly, we have shown that the liposome-breaking peptides are effective in-vitro. The battle is ongoing ♪ but we are finding hope, and not giving up. We will find, and we will bind!

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Duration: 3 minutes and 1 second
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Language: English
License: Dotsub - Standard License
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Posted by: tudresden.biomod on Oct 19, 2018

The 2018 TU Dresden BIOMOD Team designed a novel, two-component drug delivery system, "Find'n'Bind".

To learn more about the project, please visit www.findnbind.com.
To learn more about BIOMOD, please visit www.biomod.net.

Acknowledgements:
"Find'n'Bind" was produced by the team members: Teodora Andrejic, Oleksandr Berezin, Vadim Bogatyr, Teresa Churner, Shanil Gandhi, Krishna Gupta, Monique Honsa, Milica Milic, Sourabh Monnappa, Mrudula Parab, Hifsa Pervez, Vinidhra Shankar, and Colette Worcester.

Faculty Mentors:
Dr. Hans-Georg Braun
Dr. Stefan Diez
Dr. James Saenz
Dr. Yixin Zhang

Special thanks to:
Dr. Alvin Kuriakose Thomas, Dr. Grzegorz Grzesiek Chwastek
Bartosz Mateusz Kasprzak for laboratory expertise
Barbara Lindemann, Anne Chesneau for their amazing administrative support
IT Facility, BIOTEC for their technical assistance
Foram Joshi and Nayan Agrawal for great discussions and assistance
Greg Specht for photography
Magnus Ksiazek and Michael Binner for use of recording and editing studio

Video Narrator:
Colette Worcester

Video Animation:
Krishna Gupta
Vinidhra Shankar

Sound/Visual Effects:
Bensound (score "Epic")
DJ Burnham (laser)
Joe Deshon (cough)
Robert Donovan (hyperspace)

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