The End of Illness - Doctor David Agus
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Thanks a lot Doctor David Agus for being here with us this morning
We are super excited to start this series of Google Hangouts with you
Since we don't have much time, let's go straight to the point.
Brandi and Doctor Rahman
are two of the producers of the healthcare track of Hack for Big Choices
and they have few questions for you so let's start!
One of the common thing that raise your work
is try to transform the power of personalized medicine
I think there's some confusion within the medical community and without
If you could talk to us about
what that exactly means to you
and speak to young entrepreneurs
who are looking for to develop supportive services for the medical community in this regard
What are the necessities and opportunities may help this concepts to develop and gain great traction?
It's a great question. The world of personalized medicine
is taking off multiple directions and means many things to many people
If I treat you based
ethnicity, presumably that's personalized medicine.
but what really mean is "precise medicine" which is the next step.
precision medicine I think there's
some confusion
sorta within the medical community and
and without I'm regarding
his term personalized medicine so if you
could kind of talk to us about what that
exactly means to you and and and and
speak to you
are young entrepreneurs the future
leaders looking to develop
supportive services for the medical
community in this regard I'm witness
says these are opportunities do you
believe me
help this concept to develop and gain
greater traction to great question I
mean the where personalized medicine is
taken of a multiple directions it means
many things to many people
I'm you know if I treat you based on
your ethnicity presumably that's
personalized medicine to
but what it really means in Kop recision
medicine which is the next step
and precision medicine is looking at
your makeup
the technologies that we have to try to
get better treatment tailored to you
historic in somewhat reduction straight
use what technologies we have like
sequence in your DNA
sequencing the DNA is cheap 1975 in the
months and owning a report
it was a hundred fifty million dollars
to seek with 1g well today cost pennies
to sequence G
so it is scaleable Chi technology we can
learn something about you as an
individual
but is one small piece to the puzzle
you really important point I want to
bring out his chin something called
coarse graining
which is it concert from physics or
photography where you take the lead to
the camera you make it
really really blurry just see the
outline of the human well that's the out
at a humid need get finer finer grain
it's you all the details
well the idea is that reaching Harley in
element
the coarse-grained element to biology in
personalized medicine
the climate modelers do it by looking at
the shape the clout
in Iran to go up twenty thousand feet
and measure the wind speed and
temperature
they just look at the shaper the clap
it's all just measuring for example
how much I moved during the day with the
device that's a coarse-grained element
and that may be just as important as me
my DNA
in correlating to health where
particular outcome
about health and so we we challenge the
entrepreneurs is think differently
don't think like everybody else jump on
the bandwagon everybody sequencing DNA
today
think differently in maybe that
measuring for example heart rate
variability
is more important than secrets in your
DNA know we relax your heart rate is
exactly even
bank and that your little bit stressed
it up by one or two milliseconds
when you're very stressed it's off by a
lot more it so their devices now they
can look it's green when you're relaxed
yellow when you're a little stressed
read when you're very stressed
it was a good mood ring at the old days
but it's got real science behind it
and that coarse-grained element can be
work or and measuring all your blood
actually looking at your DNA
so we challenge you to be different and
measure it different aspect
%uh each of us so that we can actually
make health care better
my K
well when I say thank you again for
joining us in taking the time to meet
with us today
donna i read your book and unless i've
seen
mayor Charlie Rose interviews and on
I really and what message that you're
getting across about us
you know taking a look at the whole
picture of treating a shed
and you know there's a couple things you
mention your book that I was hoping I
could
it maybe expand a little bit on for me
or
I'm one of them was I'm talking about
you know Research Group N and citizen
scientists
um peer to peer review and
on my question is do you think that will
be
getting to a point where patients will
be empowered and engage your
kinda get some feedback and join and
I'm discussed some of these I'm so the
research
are not we better YUM
hum you know missin immediate future
treating disease a cure diseases can be
with all of us
is going to change from the bottom up
not the top down
and so historically its we docs make
decisions are made to feel change
and obviously we didn't do that could
have a job and so whether it is citizen
scientists it be the patient group where
the family members a patient's
we have to start to do things
differently and that requires a couple a
substrate changes first
rate one is we need to do with price so
we need to figure out a way so that the
privacy laws don't really black all of
us
if I told you log into wells Fargo & you
know I
here bill you wouldn't think twice if I
told you got your doctor's office
take your health care information is
sent it to somebody else people
cry foul we need to figure out a better
way so that we can all understand what
are the risks the benefits sharing data
and that really goes to the key
component that's missing now which is
standard I stayed
elements we can all share in learn
together if we all use the same language
but historically we have it in our field
you called a broken leg
you call a fractured leg so matter how
much hard work you do
the databases don't talk indeed on iraq
we need to agree on one of the common
data on its
common language for all issues right now
they're six dominate ones in the country
somebody has to take a stand and say
listen everything going for is gonna be
with one said elements
and then we can all share withdraw your
act into how we do it
there needs to be transparency with who
we are and what we are
what are the biggest problems we face
now was hearing healthcare information
is it gets corrupted because somebody
comes in acts like
there a piece with the disease are part
of a group in actuality there a sales
person trying to sell something
and if they take this a said the patient
I had this drug in it changed my life
then there likely to get your supporters
in buying the drug
well that's not what this information
needs to be use for
to the needs to be awaited verify
identify use comment data elements
all start to speak the same language
with real crime see
in we're gonna make a difference your
other ways other fields have done is to
have a broker in the middle
so that there's somebody there verifies
identities
and at the same time is able to ensure
privacy by sometimes take not
identifiers
right means that things about you see
your information
can be used by the researchers for other
citizen scientist
to make progress in a disease every
patient I have
I say listen do you want your
information to be part of the QR
for your children and grandchildren I
have never had somebody see
no thank you
I totally agree with you that day
identify patient data come the more
people that are willing to share that
bigger changes that we can make and i
think thats I'm
once we have that system in place we're
really going to see
transition for Asian Age that
Sam and down so many other questions I
had for us.
I'm I'll nutrition and preventive care
so maybe we can catch on to bed on how
the environment and I'm
in nutrition plays a role in and
Prevention house and what we can do to
you
kindness improve yeah so
it big big topic but real an important
you know we did a story with Charlie
Rose night yes six people who were
where it was really a great deal any
other two major centres at Harvard
and I'll London showing that the closer
you live near the airport
the higher your risk was a party's this
was really well control for
socioeconomic factors and very well
and so this stress and hearing the
planes land all the time
raise blood pressure raise heart disease
in the British to actually raise death
rates
and so when you go to your doctor right
now it's what's your cholesterol what's
your way
in the future the doctors who say we
should today start to say where you live
what's your environment is their stress
there just like neds to you
what do you eat what's your meal
schedule what supplements you take
all those going to risk whether he
elevated risk for lower-risk
your cholesterol value is a relative
risk value
if your cholesterol values up doesn't
mean you're gonna get heart disease
it means you're higher likelihood and
have rich it's down
doesn't mean you're not going to get
heart disease major slightly lower risk
an average it so all these factors
billion
and so in the end that was can be true
personalized medicine as we take into
account
your environment your diet the things
you do during the day
as well as you genetics in your lap
you know most I mean diseases heart
disease cancer and Alzheimer's
their only 50 percent genetic the fifty
percent
environment you could blame your parents
for a half
but the other half your rent controls
so maybe many seniors economy
our heat Miami spec are our
nice I'm no question and then to do it
in a fashion that regards data every
time there's a very well-done study
really has been replicated in really
make sense we have to say
this is validated sites we had to resort
to peddle need
act on and so what we're doing now
unfortunate through the media is
retreating everything the same
poor study in a great stay wit reading
the same with the scene had a press
release
and at some point we'll have a right to
do whatever we want
we can smoke we could drink so we can
sit on the council day
but it somehow we have to do the right
thing and we have to say with scientific
data
hit critical mass we need it act on it
and we need to create movements to act i
in order to change health care it's
what's necessary
health care in the United States is each
year and a half percent of gross
domestic product it is growing
it is one of the biggest problems we
have in the action we take his
all-around
healthcare finance we need to start
taking action around health care
that hasn't happened yet well thank you
so much for sharing
are all the smokin siphoned gas
and II who will be home for a pretty
fast
pattern over the coming months so we are
our project in school haha could be
chances because you wanna
how meaning correspondent people who are
around the world to use their past me
each ICAC get back to her not her
education in our Design Inc
marks room %uh I will have to ask you
what is being
your RBS Chinese rather have the
required to use less
your comment and you're not rich
renew my biggest choice your BS
make run you are you waiting for make
has been hard for them to make that
that chance we know how important for us
you know I been a cancer researcher and
doctor for many years
and historically the doctors in one
domain I'm in the lab minute arrest
forty people my laboratory
developing new drugs in new technologies
I treat patients
and so the choice to actually start to
be a spokesperson to work with the media
wasn't very different thing for somebody
in my situation to do
it was very still scary many which is
the doctors push you aside when you
start to work with the media
but it really is my obligation to
educate
you know I started to look and say I can
make the changes in the laboratory
develop new drugs and treatments that's
great
but at the same time I don't question
the things we know whether it be
changing behavior
understanding in room really a
comprehension of Science
that happen done fall impact that I need
to
and so I made the decision to actually
work with the media
to do CBS is twice a week or once a week
some weeks you know with Charlie Rose
the team in CBS's more you try to make a
difference
and a lot of people look down on it but
it to me it's my obligation
I have to push in this is a way we can
make a big impact on society
when cases I have great message so yeah
few minutes left I have a brand new room
on Yahoo ok anything I think that's lost
internet echoes
you have a real quick question um wanna
be a
won the primary topics that where we're
looking to address in a
in terms over the hackathon no there
we're putting forward
is the idea ever confronting depression
and helping to bring out mental health
issues
more out of the shadows and into the
forefront as far as a
a a ideas that day that young people can
think about it in terms of developing
ideas in the medical
the medical spear um can you speak a
little bit about it so the effect that
depression
educ I'm on your your particular patient
population
um that are necessarily often Associated
a without with traditional depression
I'm so there to assets under pressure
one is I mean you're right it is an
enormous drain on society
end on the individual and on their
family and it's a topic that we need to
bring out to the open
it's a we can talk about it all we want
it's not make much of an impact
as if we develop the technology to
assess its
the hardest part about depression is is
that it's a moment in time when I talk
to a patient
so I say how you feeling alright today
even though the last 29 days they were
depressed and not contributing like the
but to their family and society so if we
had
while long-term metrics for and
technology actually use
to quantitative we will be able to
improve the feel better and get better
ways
to treated to prevent it and to deal
with it
you know I dude pressure right now is he
very qualitative think you ask a couple
of questions you get answers back
when you're depressed your hope he feels
differently so there should be ways we
can measure that
both initial my heart in the long run
you know the diabetes world changed when
we were able to develop my test the
scheme in 90 day average in the sugar
makes everybody the day before they go
to the doctor to eat the right thing
they do the right thing in a blood test
looks great
but by that 90 day average we transform
how we deal with people with diabetes
well wouldn't it be neat if we had same
thing to measure mental health
and I think technology is really good
allow us to be quantitative
to develop drugs better use them in the
right person use behavior modification
better
and develop ways to actually change the
way we think and behave
and so we have been focused on that
historically if you look at the
percentage of
Thank you guys for what you are doing
we need people like you in the space. We are generating tons of data
every day but we never use it. We never can prove what we do
and we need you to do it!
When John Kennedy said " We are gonna put a man on the moon", people thought he was cazy
one year later Neil Armstrong step on the moon, when the average age
when Neil Armstrong step on the moon, a missile command was 27 years old,
which means those kids where 18 years old when Kennedy made his proclamation
I can say whatever I want but is your generation
that actually make the difference. We need you on our domain because we are not doing that well right now.
You have all my resources and our team to help move field forward. Thank You!
Thank you so much, have a great day.
Thank you, bye bye Doctor David Agus