Tom Cech Interview - What did you receive the Nobel Prize for? - Transcribed

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Duration: 1 minute and 45 seconds

Country: Sweden

Language: English

License: CC - Attribution Non-commercial No Derivatives

Genre: Documentary

Producer: MoleClues TV

Director: Per Thoren

Views: 33 (7 embedded)

Posted by: locumele on Sep 23, 2009

Nobel Prize winner Tom Cech interviewed for MoleClues. Entire interview available on www.MoleClues.org

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Prior to our studies, there had been some speculation that...
...perhaps RNA could be doing more than just serving as a messenger.
The traditional view is that DNA stores information...
...that information is transferred into an RNA transcript...
...which then serves as a message...
...and encodes the order of amino acids that are laid down in a protein...
...and that DNA is the important informational molecule...
...that protein is the molecule that’s all the enzymes and the cellular structures -
– proteins sort of doing all the work –
and RNA is just a passive intermediate in this process.
Instead, we found something very different and I think now very exciting,
because there are so many more examples,
which is that we found the first example where an RNA molecule...
...could itself perform a chemical reaction.
So the RNA, and the particular reaction was RNA splicing,
folds up into a particular, three-dimensional structure that then catalyzes cutting...
...and rejoining of chemical bonds within the RNA to remove an intron...
...and restore a sequence of RNA which is then useful for the cell.
So this turned out to be a change in the concept:
RNA not just an intermediate in a pathway, but instead RNA by itself could be...
...performing reactions in the cell.