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Transcript for Tom Cech Interview - How can we use knowledge of telomerase to cure disease?
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| Time | Content |
|---|---|
| 00:01 → 00:07 |
One promising approach has to do with various forms of cancer. |
| 00:08 → 00:17 |
Telomerase is active in humans during early life, when the cells are growing rapidly, |
| 00:17 → 00:23 |
but in adults, most tissues do not make telomerase anymore... |
| 00:23 → 00:30 |
...and cells do not have the same immortal capability that stem cells have ... |
| 00:30 → 00:34 |
...or that sex cells - germline cells - have. |
| 00:35 → 00:41 |
Cancer cells are immortal and in that case, that’s bad for us that they’re immortal... |
| 00:41 → 00:46 |
...because that means that the tumor is just going to keep dividing indefinitely. |
| 00:47 → 00:50 |
The way that they achieve this, in part, |
| 00:50 → 00:58 |
is by reactivating this telomerase enzyme, which was turned off in most adult tissues, |
| 00:58 → 01:07 |
and that reactivation is critical and necessary for uncontrolled cell division in a tumor. |
| 01:08 → 01:15 |
Therefore, any kind of approach that would inhibit or stop the telomerase enzyme... |
| 01:15 → 01:21 |
...from working in cancer cells would be a very broad-based anti-cancer therapy. |
| 01:21 → 01:26 |
So that’s one importance of this research in the medical arena. |