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Tom Cech Interview - How can we use knowledge of telomerase to cure disease?
Duration:
1 minute and 27 seconds
Country:
Sweden
Language:
English
License:
CC - Attribution Non-commercial No Derivatives
Genre:
Documentary
Producer:
MoleClues TV
Director:
Per Thoren
Views:
75 (9 embedded)
Posted by:
locumele
on Sep 23, 2009
Nobel Prize winner Tom Cech interviewed for MoleClues.org
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Video Transcription
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One promising approach has to do with various forms of cancer.
Telomerase is active in humans during early life, when the cells are growing rapidly,
but in adults, most tissues do not make telomerase anymore...
...and cells do not have the same immortal capability that stem cells have ...
...or that sex cells - germline cells - have.
Cancer cells are immortal and in that case, that’s bad for us that they’re immortal...
...because that means that the tumor is just going to keep dividing indefinitely.
The way that they achieve this, in part,
is by reactivating this telomerase enzyme, which was turned off in most adult tissues,
and that reactivation is critical and necessary for uncontrolled cell division in a tumor.
Therefore, any kind of approach that would inhibit or stop the telomerase enzyme...
...from working in cancer cells would be a very broad-based anti-cancer therapy.
So that’s one importance of this research in the medical arena.
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